Mesenchymal stem cells (MSCs) are prototypical adult stem cells with the capacity for self-renewal and differentiation with a broad\r\ntissue distribution. MSCs not only differentiate into types of cells of mesodermal lineage but also into endodermal and ectodermal\r\nlineages such as bone, fat, cartilage and cardiomyocytes, endothelial cells, lung epithelial cells, hepatocytes, neurons, and pancreatic\r\nislets. MSCs have been identified as an adherent, fibroblast-like population and can be isolated fromdifferent adult tissues, including\r\nbone marrow (BM), umbilical cord, skeletal muscle, and adipose tissue. MSCs secrete factors, including IL-6, M-CSF, IL-10, HGF,\r\nand PGE2, that promote tissue repair, stimulate proliferation and differentiation of endogenous tissue progenitors, and decrease\r\ninflammatory and immune reactions. In this paper, we focus on the role of BM-derived MSCs in organ repair.
Loading....